http://barf.jcowboy.org Nature recent publications en-us http://barf.jcowboy.org/pubmed.gif http://barf.jcowboy.org http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480823 Publication Date: 2008 May 15 PMID: 18480823<br/>Authors: Bradshaw, H.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480823&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480822 Publication Date: 2008 May 15 PMID: 18480822<br/>Authors: Loulergue, L. - Schilt, A. - Spahni, R. - Masson-Delmotte, V. - Blunier, T. - Lemieux, B. - Barnola, J. M. - Raynaud, D. - Stocker, T. F. - Chappellaz, J.<br/>Journal: Nature<br/><br/>Atmospheric methane is an important greenhouse gas and a sensitive indicator of climate change and millennial-scale temperature variability. Its concentrations over the past 650,000 years have varied between approximately 350 and approximately 800 parts per 10(9) by volume (p.p.b.v.) during glacial and interglacial periods, respectively. In comparison, present-day methane levels of approximately 1,770 p.p.b.v. have been reported. Insights into the external forcing factors and internal feedbacks controlling atmospheric methane are essential for predicting the methane budget in a warmer world. Here we present a detailed atmospheric methane record from the EPICA Dome C ice core that extends the history of this greenhouse gas to 800,000 yr before present. The average time resolution of the new data is approximately 380 yr and permits the identification of orbital and millennial-scale features. Spectral analyses indicate that the long-term variability in atmospheric methane levels is dominated by approximately 100,000 yr glacial-interglacial cycles up to approximately 400,000 yr ago with an increasing contribution of the precessional component during the four more recent climatic cycles. We suggest that changes in the strength of tropical methane sources and sinks (wetlands, atmospheric oxidation), possibly influenced by changes in monsoon systems and the position of the intertropical convergence zone, controlled the atmospheric methane budget, with an additional source input during major terminations as the retreat of the northern ice sheet allowed higher methane emissions from extending periglacial wetlands. Millennial-scale changes in methane levels identified in our record as being associated with Antarctic isotope maxima events are indicative of ubiquitous millennial-scale temperature variability during the past eight glacial cycles.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480822&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480821 Publication Date: 2008 May 15 PMID: 18480821<br/>Authors: Luthi, D. - Le Floch, M. - Bereiter, B. - Blunier, T. - Barnola, J. M. - Siegenthaler, U. - Raynaud, D. - Jouzel, J. - Fischer, H. - Kawamura, K. - Stocker, T. F.<br/>Journal: Nature<br/><br/>Changes in past atmospheric carbon dioxide concentrations can be determined by measuring the composition of air trapped in ice cores from Antarctica. So far, the Antarctic Vostok and EPICA Dome C ice cores have provided a composite record of atmospheric carbon dioxide levels over the past 650,000 years. Here we present results of the lowest 200 m of the Dome C ice core, extending the record of atmospheric carbon dioxide concentration by two complete glacial cycles to 800,000 yr before present. From previously published data and the present work, we find that atmospheric carbon dioxide is strongly correlated with Antarctic temperature throughout eight glacial cycles but with significantly lower concentrations between 650,000 and 750,000 yr before present. Carbon dioxide levels are below 180 parts per million by volume (p.p.m.v.) for a period of 3,000 yr during Marine Isotope Stage 16, possibly reflecting more pronounced oceanic carbon storage. We report the lowest carbon dioxide concentration measured in an ice core, which extends the pre-industrial range of carbon dioxide concentrations during the late Quaternary by about 10 p.p.m.v. to 172-300 p.p.m.v.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480821&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480820 Publication Date: 2008 May 15 PMID: 18480820<br/>Authors: Tsintzos, S. I. - Pelekanos, N. T. - Konstantinidis, G. - Hatzopoulos, Z. - Savvidis, P. G.<br/>Journal: Nature<br/><br/>The increasing ability to control light-matter interactions at the nanometre scale has improved the performance of semiconductor lasers in the past decade. The ultimate optimization is realized in semiconductor microcavities, in which strong coupling between quantum-well excitons and cavity photons gives rise to hybrid half-light/half-matter polariton quasiparticles. The unique properties of polaritons-such as stimulated scattering, parametric amplification, lasing, condensation and superfluidity-are believed to provide the basis for a new generation of polariton emitters and semiconductor lasers. Until now, polariton lasing and nonlinearities have only been demonstrated in optical experiments, which have shown the potential to reduce lasing thresholds by two orders of magnitude compared to conventional semiconductor lasers. Here we report an experimental realization of an electrically pumped semiconductor polariton light-emitting device, which emits directly from polariton states at a temperature of 235 K. Polariton electroluminescence data reveal characteristic anticrossing between exciton and cavity modes, a clear signature of the strong coupling regime. These findings represent a substantial step towards the realization of ultra-efficient polaritonic devices with unprecedented characteristics.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480820&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480819 Publication Date: 2008 May 15 PMID: 18480819<br/>Authors: Schenk, P. - Matsuyama, I. - Nimmo, F.<br/>Journal: Nature<br/><br/>The tectonic patterns and stress history of Europa are exceedingly complex and many large-scale features remain unexplained. True polar wander, involving reorientation of Europa's floating outer ice shell about the tidal axis with Jupiter, has been proposed as a possible explanation for some of the features. This mechanism is possible if the icy shell is latitudinally variable in thickness and decoupled from the rocky interior. It would impose high stress levels on the shell, leading to predictable fracture patterns. No satisfactory match to global-scale features has hitherto been found for polar wander stress patterns. Here we describe broad arcuate troughs and depressions on Europa that do not fit other proposed stress mechanisms in their current position. Using imaging from three spacecraft, we have mapped two global-scale organized concentric antipodal sets of arcuate troughs up to hundreds of kilometres long and 300 m to approximately 1.5 km deep. An excellent match to these features is found with stresses caused by an episode of approximately 80 degrees true polar wander. These depressions also appear to be geographically related to other large-scale bright and dark lineaments, suggesting that many of Europa's tectonic patterns may also be related to true polar wander.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480819&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480818 Publication Date: 2008 May 15 PMID: 18480818<br/>Authors: Murakami, M. - Kouyama, T.<br/>Journal: Nature<br/><br/>Invertebrate phototransduction uses an inositol-1,4,5-trisphosphate signalling cascade in which photoactivated rhodopsin stimulates a G(q)-type G protein, that is, a class of G protein that stimulates membrane-bound phospholipase Cbeta. The same cascade is used by many G-protein-coupled receptors, indicating that invertebrate rhodopsin is a prototypical member. Here we report the crystal structure of squid (Todarodes pacificus) rhodopsin at 2.5 A resolution. Among seven transmembrane alpha-helices, helices V and VI extend into the cytoplasmic medium and, together with two cytoplasmic helices, they form a rigid protrusion from the membrane surface. This peculiar structure, which is not seen in bovine rhodopsin, seems to be crucial for the recognition of G(q)-type G proteins. The retinal Schiff base forms a hydrogen bond to Asn 87 or Tyr 111; it is far from the putative counterion Glu 180. In the crystal, a tight association is formed between the amino-terminal polypeptides of neighbouring monomers; this intermembrane dimerization may be responsible for the organization of hexagonally packed microvillar membranes in the photoreceptor rhabdom.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480818&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480817 Publication Date: 2008 May 15 PMID: 18480817<br/>Authors: Rosenzweig, C. - Karoly, D. - Vicarelli, M. - Neofotis, P. - Wu, Q. - Casassa, G. - Menzel, A. - Root, T. L. - Estrella, N. - Seguin, B. - Tryjanowski, P. - Liu, C. - Rawlins, S. - Imeson, A.<br/>Journal: Nature<br/><br/>Significant changes in physical and biological systems are occurring on all continents and in most oceans, with a concentration of available data in Europe and North America. Most of these changes are in the direction expected with warming temperature. Here we show that these changes in natural systems since at least 1970 are occurring in regions of observed temperature increases, and that these temperature increases at continental scales cannot be explained by natural climate variations alone. Given the conclusions from the Intergovernmental Panel on Climate Change (IPCC) Fourth Assessment Report that most of the observed increase in global average temperatures since the mid-twentieth century is very likely to be due to the observed increase in anthropogenic greenhouse gas concentrations, and furthermore that it is likely that there has been significant anthropogenic warming over the past 50 years averaged over each continent except Antarctica, we conclude that anthropogenic climate change is having a significant impact on physical and biological systems globally and in some continents.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480817&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480816 Publication Date: 2008 May 15 PMID: 18480816<br/>Authors: Schroeder, T.<br/>Journal: Nature<br/><br/>The ability to observe biological processes continuously, instead of at discrete time points, holds great promise for the study of tissue regeneration. Ideally, single cells would be followed continuously within large tissue volumes (such as organs) over long periods of time. Technical limitations, however, preclude such studies. But, recently, there have been improvements in imaging technologies and biologically compatible labelling agents. Together with new insights into the molecular characteristics of stem cells, which are ultimately responsible for the regenerative potential of all tissues, researchers are now much closer to applying single-cell imaging approaches to research into regeneration and its clinical applications.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480816&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480815 Publication Date: 2008 May 15 PMID: 18480815<br/>Authors: Xu, Y. - Shi, Y. - Ding, S.<br/>Journal: Nature<br/><br/>An improved understanding of stem-cell and regenerative biology, as well as a better control of stem-cell fate, is likely to produce treatments for many devastating diseases and injuries. Chemical approaches are starting to have an increasingly important role in this young field. Attention has focused on chemical approaches that allow the precise manipulation of cells in vitro to obtain homogeneous cell types for cell-based therapies. Another promising approach is the development of conventional chemical and biological therapeutics to stimulate endogenous cells to regenerate. Such therapeutics can act on target cells or their niches in vivo to promote cell survival, proliferation, differentiation, reprogramming and homing.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480815&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480814 Publication Date: 2008 May 15 PMID: 18480814<br/>Authors: Chidgey, A. P. - Layton, D. - Trounson, A. - Boyd, R. L.<br/>Journal: Nature<br/><br/>There is much interest in using embryonic stem cells to regenerate tissues and organs. For this approach to succeed, these stem cells or their derivatives must engraft in patients over the long term. Unless a cell transplant is derived from the patient's own cells, however, the cells will be targeted for rejection by the immune system. Although standard methods for suppressing the immune system achieve some success, rejection of the transplant is inevitable. Emerging approaches to address this issue include 're-educating' the immune system to induce tolerance to foreign cells and reducing the immune targeting of the transplant by administering 'self stem cells' instead of foreign cells, but each of these approaches has associated challenges.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480814&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480813 Publication Date: 2008 May 15 PMID: 18480813<br/>Authors: Passier, R. - van Laake, L. W. - Mummery, C. L.<br/>Journal: Nature<br/><br/>The potential usefulness of human embryonic stem cells for therapy derives from their ability to form any cell in the body. This potential has been used to justify intensive research despite some ethical concerns. In parallel, scientists have searched for adult stem cells that can be used as an alternative to embryonic cells, and, for the heart at least, these efforts have led to promising results. However, most adult cardiomyocytes are unable to divide and form new cardiomyocytes and would therefore be unable to replace those lost as a result of disease. Basic questions--for example, whether cardiomyocyte replacement or alternatives, such as providing the damaged heart with new blood vessels or growth factors to activate resident stem cells, are the best approach--remain to be fully addressed. Despite this, preclinical studies on cardiomyocyte transplantation in animals and the first clinical trials with adult stem cells have recently been published with mixed results.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480813&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480812 Publication Date: 2008 May 15 PMID: 18480812<br/>Authors: Gurtner, G. C. - Werner, S. - Barrandon, Y. - Longaker, M. T.<br/>Journal: Nature<br/><br/>The repair of wounds is one of the most complex biological processes that occur during human life. After an injury, multiple biological pathways immediately become activated and are synchronized to respond. In human adults, the wound repair process commonly leads to a non-functioning mass of fibrotic tissue known as a scar. By contrast, early in gestation, injured fetal tissues can be completely recreated, without fibrosis, in a process resembling regeneration. Some organisms, however, retain the ability to regenerate tissue throughout adult life. Knowledge gained from studying such organisms might help to unlock latent regenerative pathways in humans, which would change medical practice as much as the introduction of antibiotics did in the twentieth century.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480812&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480811 Publication Date: 2008 May 15 PMID: 18480811<br/>Authors: Zon, L. I.<br/>Journal: Nature<br/><br/>When stem cells divide, they can generate progeny with the same developmental potential as the original cell, a process referred to as self-renewal. Self-renewal is driven intrinsically by gene expression in a cell-type-specific manner and is modulated through interactions with extrinsic cues from the environment, such as growth factors. However, despite the prevalence of the term self-renewal in the scientific literature, this process has not been defined at the molecular level. Haematopoietic stem cells are an excellent model for the study of self-renewal because they can be isolated prospectively, manipulated relatively easily and assessed by using well-defined assays. Establishing the principles of self-renewal in haematopoietic stem cells will lead to insights into the mechanisms of self-renewal in other tissues.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480811&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480810 Publication Date: 2008 May 15 PMID: 18480810<br/>Authors: Chien, K. R.<br/>Journal: Nature<br/><br/>Recent advances in stem-cell technology are now allowing the mechanisms of human disease to be studied in human cells. A new era for regenerative medicine is arising from such disease models, extending beyond early cell-based therapies and towards evaluating genetic variation in humans and identifying the molecular pathways that lead to disease, as well as targets for therapy.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480810&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480809 Publication Date: 2008 May 15 PMID: 18480809<br/>Authors: DeWitt, N.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480809&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480808 Publication Date: 2008 May 15 PMID: 18480808<br/>Authors: Ott, E.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480808&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480807 Publication Date: 2008 May 15 PMID: 18480807<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480807&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480806 Publication Date: 2008 May 15 PMID: 18480806<br/>Authors: Friml, J. - Sauer, M.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480806&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480805 Publication Date: 2008 May 15 PMID: 18480805<br/>Authors: Deveaud-Pledran, B.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480805&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480804 Publication Date: 2008 May 15 PMID: 18480804<br/>Authors: Zwiers, F. - Hegerl, G.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480804&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480803 Publication Date: 2008 May 15 PMID: 18480803<br/>Authors: Kaufmann, S. H.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480803&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480802 Publication Date: 2008 May 15 PMID: 18480802<br/>Authors: Kwiat, P. G.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480802&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480801 Publication Date: 2008 May 15 PMID: 18480801<br/>Authors: Schertler, G. F.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480801&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480800 Publication Date: 2008 May 15 PMID: 18480800<br/>Authors: Brook, E.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480800&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480799 Publication Date: 2008 May 15 PMID: 18480799<br/>Authors: Fauci, A. S.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480799&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480798 Publication Date: 2008 May 15 PMID: 18480798<br/>Authors: McDermott, J.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480798&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480797 Publication Date: 2008 May 15 PMID: 18480797<br/>Authors: Turner, C.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480797&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480796 Publication Date: 2008 May 15 PMID: 18480796<br/>Authors: Warner, D. J.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480796&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480795 Publication Date: 2008 May 15 PMID: 18480795<br/>Authors: Jackson, E.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480795&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480794 Publication Date: 2008 May 15 PMID: 18480794<br/>Authors: Sargent, M.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480794&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480793 Publication Date: 2008 May 15 PMID: 18480793<br/>Authors: Roche, M. I.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480793&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480792 Publication Date: 2008 May 15 PMID: 18480792<br/>Authors: Robbins, A.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480792&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480791 Publication Date: 2008 May 15 PMID: 18480791<br/>Authors: Goodman, N. W.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480791&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480790 Publication Date: 2008 May 15 PMID: 18480790<br/>Authors: Spiegel, S. J.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480790&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480789 Publication Date: 2008 May 15 PMID: 18480789<br/>Authors: Barbosa, A. F.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480789&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480788 Publication Date: 2008 May 15 PMID: 18480788<br/>Authors: Kostarelos, K. - Bianco, A. - Prato, M.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480788&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480787 Publication Date: 2008 May 15 PMID: 18480787<br/>Authors: Wenner, M.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480787&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480786 Publication Date: 2008 May 15 PMID: 18480786<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480786&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480785 Publication Date: 2008 May 15 PMID: 18480785<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480785&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480784 Publication Date: 2008 May 15 PMID: 18480784<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480784&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480783 Publication Date: 2008 May 15 PMID: 18480783<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480783&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480782 Publication Date: 2008 May 15 PMID: 18480782<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480782&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480781 Publication Date: 2008 May 15 PMID: 18480781<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480781&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480780 Publication Date: 2008 May 15 PMID: 18480780<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480780&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480779 Publication Date: 2008 May 15 PMID: 18480779<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480779&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480778 Publication Date: 2008 May 15 PMID: 18480778<br/>Authors: Heffernan, O.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480778&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480777 Publication Date: 2008 May 15 PMID: 18480777<br/>Authors: Brumfiel, G.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480777&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480776 Publication Date: 2008 May 15 PMID: 18480776<br/>Authors: Petherick, A.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480776&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480775 Publication Date: 2008 May 15 PMID: 18480775<br/>Authors: Sanderson, K.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480775&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480774 Publication Date: 2008 May 15 PMID: 18480774<br/>Authors: Schiermeier, Q.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480774&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480773 Publication Date: 2008 May 15 PMID: 18480773<br/>Authors: Tollefson, J.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480773&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480772 Publication Date: 2008 May 15 PMID: 18480772<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480772&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480771 Publication Date: 2008 May 15 PMID: 18480771<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480771&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480770 Publication Date: 2008 May 15 PMID: 18480770<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480770&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480769 Publication Date: 2008 May 15 PMID: 18480769<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480769&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480768 Publication Date: 2008 May 15 PMID: 18480768<br/>Authors: Bergstrom, C.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480768&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480767 Publication Date: 2008 May 15 PMID: 18480767<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480767&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480766 Publication Date: 2008 May 15 PMID: 18480766<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480766&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480765 Publication Date: 2008 May 15 PMID: 18480765<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480765&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480764 Publication Date: 2008 May 15 PMID: 18480764<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480764&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480763 Publication Date: 2008 May 15 PMID: 18480763<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480763&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480762 Publication Date: 2008 May 15 PMID: 18480762<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480762&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480761 Publication Date: 2008 May 15 PMID: 18480761<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480761&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480760 Publication Date: 2008 May 15 PMID: 18480760<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480760&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480759 Publication Date: 2008 May 15 PMID: 18480759<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480759&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480758 Publication Date: 2008 May 15 PMID: 18480758<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480758&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480757 Publication Date: 2008 May 15 PMID: 18480757<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480757&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480756 Publication Date: 2008 May 15 PMID: 18480756<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480756&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480755 Publication Date: 2008 May 14 PMID: 18480755<br/>Authors: Cavey, M. - Rauzi, M. - Lenne, P. F. - Lecuit, T.<br/>Journal: Nature<br/><br/>Epithelial tissues maintain a robust architecture which is important for their barrier function, but they are also remodelled through the reorganization of cell-cell contacts. Tissue stability requires intercellular adhesion mediated by E-cadherin, in particular its trans-association in homophilic complexes supported by actin filaments through beta- and alpha-catenin. How alpha-catenin dynamic interactions between E-cadherin/beta-catenin and cortical actin control both stability and remodelling of adhesion is unclear. Here we focus on Drosophila homophilic E-cadherin complexes rather than total E-cadherin, including diffusing 'free' E-cadherin, because these complexes are a better proxy for adhesion. We find that E-cadherin complexes partition in very stable microdomains (that is, bona fide adhesive foci which are more stable than remodelling contacts). Furthermore, we find that stability and mobility of these microdomains depend on two actin populations: small, stable actin patches concentrate at homophilic E-cadherin clusters, whereas a rapidly turning over, contractile network constrains their lateral movement by a tethering mechanism. alpha-Catenin controls epithelial architecture mainly through regulation of the mobility of homophilic clusters and it is largely dispensable for their stability. Uncoupling stability and mobility of E-cadherin complexes suggests that stable epithelia may remodel through the regulated mobility of very stable adhesive foci.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480755&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480754 Publication Date: 2008 May 14 PMID: 18480754<br/>Authors: Collins, P. J. - Haire, L. F. - Lin, Y. P. - Liu, J. - Russell, R. J. - Walker, P. A. - Skehel, J. J. - Martin, S. R. - Hay, A. J. - Gamblin, S. J.<br/>Journal: Nature<br/><br/>The potential impact of pandemic influenza makes effective measures to limit the spread and morbidity of virus infection a public health priority. Antiviral drugs are seen as essential requirements for control of initial influenza outbreaks caused by a new virus, and in pre-pandemic plans there is a heavy reliance on drug stockpiles. The principal target for these drugs is a virus surface glycoprotein, neuraminidase, which facilitates the release of nascent virus and thus the spread of infection. Oseltamivir (Tamiflu) and zanamivir (Relenza) are two currently used neuraminidase inhibitors that were developed using knowledge of the enzyme structure. It has been proposed that the closer such inhibitors resemble the natural substrate, the less likely they are to select drug-resistant mutant viruses that retain viability. However, there have been reports of drug-resistant mutant selection in vitro and from infected humans. We report here the enzymatic properties and crystal structures of neuraminidase mutants from H5N1-infected patients that explain the molecular basis of resistance. Our results show that these mutants are resistant to oseltamivir but still strongly inhibited by zanamivir owing to an altered hydrophobic pocket in the active site of the enzyme required for oseltamivir binding. Together with recent reports of the viability and pathogenesis of H5N1 (ref. 7) and H1N1 (ref. 8) viruses with neuraminidases carrying these mutations, our results indicate that it would be prudent for pandemic stockpiles of oseltamivir to be augmented by additional antiviral drugs, including zanamivir.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480754&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480753 Publication Date: 2008 May 14 PMID: 18480753<br/>Authors: Hafting, T. - Fyhn, M. - Bonnevie, T. - Moser, M. B. - Moser, E. I.<br/>Journal: Nature<br/><br/>Theta-phase precession in hippocampal place cells is one of the best-studied experimental models of temporal coding in the brain. Theta-phase precession is a change in spike timing in which the place cell fires at progressively earlier phases of the extracellular theta rhythm as the animal crosses the spatially restricted firing field of the neuron. Within individual theta cycles, this phase advance results in a compressed replication of the firing sequence of consecutively activated place cells along the animal's trajectory, at a timescale short enough to enable spike-time-dependent plasticity between neurons in different parts of the sequence. The neuronal circuitry required for phase precession has not yet been established. The fact that phase precession can be seen in hippocampal output stuctures such as the prefrontal cortex suggests either that efferent structures inherit the precession from the hippocampus or that it is generated locally in those structures. Here we show that phase precession is expressed independently of the hippocampus in spatially modulated grid cells in layer II of medial entorhinal cortex, one synapse upstream of the hippocampus. Phase precession is apparent in nearly all principal cells in layer II but only sparsely in layer III. The precession in layer II is not blocked by inactivation of the hippocampus, suggesting that the phase advance is generated in the grid cell network. The results point to possible mechanisms for grid formation and raise the possibility that hippocampal phase precession is inherited from entorhinal cortex.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480753&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18480752 Publication Date: 2008 May 14 PMID: 18480752<br/>Authors: Cai, C. L. - Martin, J. C. - Sun, Y. - Cui, L. - Wang, L. - Ouyang, K. - Yang, L. - Bu, L. - Liang, X. - Zhang, X. - Stallcup, W. B. - Denton, C. P. - McCulloch, A. - Chen, J. - Evans, S. M.<br/>Journal: Nature<br/><br/>Understanding the origins and roles of cardiac progenitor cells is important for elucidating the pathogenesis of congenital and acquired heart diseases. Moreover, manipulation of cardiac myocyte progenitors has potential for cell-based repair strategies for various myocardial disorders. Here we report the identification in mouse of a previously unknown cardiac myocyte lineage that derives from the proepicardial organ. These progenitor cells, which express the T-box transcription factor Tbx18, migrate onto the outer cardiac surface to form the epicardium, and then make a substantial contribution to myocytes in the ventricular septum and the atrial and ventricular walls. Tbx18-expressing cardiac progenitors also give rise to cardiac fibroblasts and coronary smooth muscle cells. The pluripotency of Tbx18 proepicardial cells provides a theoretical framework for applying these progenitors to effect cardiac repair and regeneration.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18480752&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18476298 Publication Date: 2008 Apr 17 PMID: 18476298<br/>Authors: Ledford, H.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18476298&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18469804 Publication Date: 2008 May 11 PMID: 18469804<br/>Authors: Shen, J. X. - Feng, A. S. - Xu, Z. M. - Yu, Z. L. - Arch, V. S. - Yu, X. J. - Narins, P. M.<br/>Journal: Nature<br/><br/>Sound communication plays a vital role in frog reproduction, in which vocal advertisement is generally the domain of males. Females are typically silent, but in a few anuran species they can produce a feeble reciprocal call or rapping sounds during courtship. Males of concave-eared torrent frogs (Odorrana tormota) have demonstrated ultrasonic communication capacity. Although females of O. tormota have an unusually well-developed vocal production system, it is unclear whether or not they produce calls or are only passive partners in a communication system dominated by males. Here we show that before ovulation, gravid females of O. tormota emit calls that are distinct from males' advertisement calls, having higher fundamental frequencies and harmonics and shorter call duration. In the field and in a quiet, darkened indoor arena, these female calls evoke vocalizations and extraordinarily precise positive phonotaxis (a localization error of <1 degrees ), rivalling that of vertebrates with the highest localization acuity (barn owls, dolphins, elephants and humans). The localization accuracy of O. tormota is remarkable in light of their small head size (interaural distance of <1 cm), and suggests an additional selective advantage of high-frequency hearing beyond the ability to avoid masking by low-frequency background noise.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18469804&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18469803 Publication Date: 2008 May 11 PMID: 18469803<br/>Authors: Kanasaki, K. - Palmsten, K. - Sugimoto, H. - Ahmad, S. - Hamano, Y. - Xie, L. - Parry, S. - Augustin, H. G. - Gattone, V. H. - Folkman, J. - Strauss, J. F. - Kalluri, R.<br/>Journal: Nature<br/><br/>Despite intense investigation, mechanisms that facilitate the emergence of the pre-eclampsia phenotype in women are still unknown. Placental hypoxia, hypertension, proteinuria and oedema are the principal clinical features of this disease. It is speculated that hypoxia-driven disruption of the angiogenic balance involving vascular endothelial growth factor (VEGF)/placenta-derived growth factor (PLGF) and soluble Fms-like tyrosine kinase-1 (sFLT-1, the soluble form of VEGF receptor 1) might contribute to some of the maternal symptoms of pre-eclampsia. However, pre-eclampsia does not develop in all women with high sFLT-1 or low PLGF levels, and it also occurs in some women with low sFLT-1 and high PLGF levels. Moreover, recent experiments strongly suggest that several soluble factors affecting the vasculature are probably elevated because of placental hypoxia in the pre-eclamptic women, indicating that upstream molecular defect(s) may contribute to pre-eclampsia. Here we show that pregnant mice deficient in catechol-O-methyltransferase (COMT) show a pre-eclampsia-like phenotype resulting from an absence of 2-methoxyoestradiol (2-ME), a natural metabolite of oestradiol that is elevated during the third trimester of normal human pregnancy. 2-ME ameliorates all pre-eclampsia-like features without toxicity in the Comt(-/-) pregnant mice and suppresses placental hypoxia, hypoxia-inducible factor-1alpha expression and sFLT-1 elevation. The levels of COMT and 2-ME are significantly lower in women with severe pre-eclampsia. Our studies identify a genetic mouse model for pre-eclampsia and suggest that 2-ME may have utility as a plasma and urine diagnostic marker for this disease, and may also serve as a therapeutic supplement to prevent or treat this disorder.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18469803&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18469802 Publication Date: 2008 May 11 PMID: 18469802<br/>Authors: Tye, K. M. - Stuber, G. D. - de Ridder, B. - Bonci, A. - Janak, P. H.<br/>Journal: Nature<br/><br/>What neural changes underlie individual differences in goal-directed learning? The lateral amygdala (LA) is important for assigning emotional and motivational significance to discrete environmental cues, including those that signal rewarding events. Recognizing that a cue predicts a reward enhances an animal's ability to acquire that reward; however, the cellular and synaptic mechanisms that underlie cue-reward learning are unclear. Here we show that marked changes in both cue-induced neuronal firing and input-specific synaptic strength occur with the successful acquisition of a cue-reward association within a single training session. We performed both in vivo and ex vivo electrophysiological recordings in the LA of rats trained to self-administer sucrose. We observed that reward-learning success increased in proportion to the number of amygdala neurons that responded phasically to a reward-predictive cue. Furthermore, cue-reward learning induced an AMPA (alpha-amino-3-hydroxy-5-methyl-isoxazole propionic acid)-receptor-mediated increase in the strength of thalamic, but not cortical, synapses in the LA that was apparent immediately after the first training session. The level of learning attained by individual subjects was highly correlated with the degree of synaptic strength enhancement. Importantly, intra-LA NMDA (N-methyl-d-aspartate)-receptor blockade impaired reward-learning performance and attenuated the associated increase in synaptic strength. These findings provide evidence of a connection between LA synaptic plasticity and cue-reward learning, potentially representing a key mechanism underlying goal-directed behaviour.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18469802&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18469801 Publication Date: 2008 May 11 PMID: 18469801<br/>Authors: Ito, K. - Bernardi, R. - Morotti, A. - Matsuoka, S. - Saglio, G. - Ikeda, Y. - Rosenblatt, J. - Avigan, D. E. - Teruya-Feldstein, J. - Pandolfi, P. P.<br/>Journal: Nature<br/><br/>The existence of a small population of 'cancer-initiating cells' responsible for tumour maintenance has been firmly demonstrated in leukaemia. This concept is currently being tested in solid tumours. Leukaemia-initiating cells, particularly those that are in a quiescent state, are thought to be resistant to chemotherapy and targeted therapies, resulting in disease relapse. Chronic myeloid leukaemia is a paradigmatic haematopoietic stem cell disease in which the leukaemia-initiating-cell pool is not eradicated by current therapy, leading to disease relapse on drug discontinuation. Here we define the critical role of the promyelocytic leukaemia protein (PML) tumour suppressor in haematopoietic stem cell maintenance, and present a new therapeutic approach for targeting quiescent leukaemia-initiating cells and possibly cancer-initiating cells by pharmacological inhibition of PML.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18469801&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18469800 Publication Date: 2008 May 11 PMID: 18469800<br/>Authors: Yang, L. - Anderson, D. E. - Baecher-Allan, C. - Hastings, W. D. - Bettelli, E. - Oukka, M. - Kuchroo, V. K. - Hafler, D. A.<br/>Journal: Nature<br/><br/>The recent discovery of CD4(+) T cells characterized by secretion of interleukin (IL)-17 (T(H)17 cells) and the naturally occurring regulatory FOXP3(+) CD4 T cell (nT(reg)) has had a major impact on our understanding of immune processes not readily explained by the T(H)1/T(H)2 paradigm. T(H)17 and nT(reg) cells have been implicated in the pathogenesis of human autoimmune diseases, including multiple sclerosis, rheumatoid arthritis, inflammatory bowel disease and psoriasis. Our recent data and the work of others demonstrated that transforming growth factor-beta (TGF-beta) and IL-6 are responsible for the differentiation of naive mouse T cells into T(H)17 cells, and it has been proposed that IL-23 may have a critical role in stabilization of the T(H)17 phenotype. A second pathway has been discovered in which a combination of TGF-beta and IL-21 is capable of inducing differentiation of mouse T(H)17 cells in the absence of IL-6 (refs 6-8). However, TGF-beta and IL-6 are not capable of differentiating human T(H)17 cells and it has been suggested that TGF-beta may in fact suppress the generation of human T(H)17 cells. Instead, it has been recently shown that the cytokines IL-1beta, IL-6 and IL-23 are capable of driving IL-17 secretion in short-term CD4(+) T cell lines isolated from human peripheral blood, although the factors required for differentiation of naive human CD4 to T(H)17 cells are still unknown. Here we confirm that whereas IL-1beta and IL-6 induce IL-17A secretion from human central memory CD4(+) T cells, TGF-beta and IL-21 uniquely promote the differentiation of human naive CD4(+) T cells into T(H)17 cells accompanied by expression of the transcription factor RORC2. These data will allow the investigation of this new population of T(H)17 cells in human inflammatory disease.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18469800&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464743 Publication Date: 2008 May 8 PMID: 18464743<br/>Authors: Boyd, J. P.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464743&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464742 Publication Date: 2008 May 8 PMID: 18464742<br/>Authors: Muneepeerakul, R. - Bertuzzo, E. - Lynch, H. J. - Fagan, W. F. - Rinaldo, A. - Rodriguez-Iturbe, I.<br/>Journal: Nature<br/><br/>River networks, seen as ecological corridors featuring connected and hierarchical dendritic landscapes for animals and plants, present unique challenges and opportunities for testing biogeographical theories and macroecological laws. Although local and basin-scale differences in riverine fish diversity have been analysed as functions of energy availability and habitat heterogeneity, scale-dependent environmental conditions and river discharge, a model that predicts a comprehensive set of system-wide diversity patterns has been hard to find. Here we show that fish diversity patterns throughout the Mississippi-Missouri River System are well described by a neutral metacommunity model coupled with an appropriate habitat capacity distribution and dispersal kernel. River network structure acts as an effective template for characterizing spatial attributes of fish biodiversity. We show that estimates of average dispersal behaviour and habitat capacities, objectively calculated from average runoff production, yield reliable predictions of large-scale spatial biodiversity patterns in riverine systems. The success of the neutral theory in two-dimensional forest ecosystems and here in dendritic riverine ecosystems suggests the possible application of neutral metacommunity models in a diverse suite of ecosystems. This framework offers direct linkage from large-scale forcing, such as global climate change, to biodiversity patterns.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464742&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464741 Publication Date: 2008 May 8 PMID: 18464741<br/>Authors: Nogues-Bravo, D. - Araujo, M. B. - Romdal, T. - Rahbek, C.<br/>Journal: Nature<br/><br/>Despite two centuries of effort in characterizing environmental gradients of species richness in search of universal patterns, surprisingly few of these patterns have been widely acknowledged. Species richness along altitudinal gradients was previously assumed to increase universally from cool highlands to warm lowlands, mirroring the latitudinal increase in species richness from cool to warm latitudes. However, since the more recent general acceptance of altitudinal gradients as model templates for testing hypotheses behind large-scale patterns of diversity, these gradients have been used in support of all the main diversity hypotheses, although little consensus has been achieved. Here we show that when resampling a data set comprising 400,000 records for 3,046 Pyrenean floristic species at different scales of analysis (achieved by varying grain size and the extent of the gradients sampled), the derived species richness pattern changed progressively from hump-shaped to a monotonic pattern as the scale of extent diminished. Scale effects alone gave rise to as many conflicting patterns of species richness as had previously been reported in the literature, and scale effects lent significantly different statistical support to competing diversity hypotheses. Effects of scale on current studies may be affected by human activities, because montane ecosystems and human activities are intimately connected. This interdependence has led to a global reduction in natural lowland habitats, hampering our ability to detect universal patterns and impeding the search for universal diversity gradients to discover the mechanisms determining the distribution of biological diversity on Earth.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464741&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464740 Publication Date: 2008 May 8 PMID: 18464740<br/>Authors: Cox, P. M. - Harris, P. P. - Huntingford, C. - Betts, R. A. - Collins, M. - Jones, C. D. - Jupp, T. E. - Marengo, J. A. - Nobre, C. A.<br/>Journal: Nature<br/><br/>The Amazon rainforest plays a crucial role in the climate system, helping to drive atmospheric circulations in the tropics by absorbing energy and recycling about half of the rainfall that falls on it. This region (Amazonia) is also estimated to contain about one-tenth of the total carbon stored in land ecosystems, and to account for one-tenth of global, net primary productivity. The resilience of the forest to the combined pressures of deforestation and global warming is therefore of great concern, especially as some general circulation models (GCMs) predict a severe drying of Amazonia in the twenty-first century. Here we analyse these climate projections with reference to the 2005 drought in western Amazonia, which was associated with unusually warm North Atlantic sea surface temperatures (SSTs). We show that reduction of dry-season (July-October) rainfall in western Amazonia correlates well with an index of the north-south SST gradient across the equatorial Atlantic (the 'Atlantic N-S gradient'). Our climate model is unusual among current GCMs in that it is able to reproduce this relationship and also the observed twentieth-century multidecadal variability in the Atlantic N-S gradient, provided that the effects of aerosols are included in the model. Simulations for the twenty-first century using the same model show a strong tendency for the SST conditions associated with the 2005 drought to become much more common, owing to continuing reductions in reflective aerosol pollution in the Northern Hemisphere.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464740&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464739 Publication Date: 2008 May 8 PMID: 18464739<br/>Authors: Wang, B. - Cote, A. P. - Furukawa, H. - O'Keeffe, M. - Yaghi, O. M.<br/>Journal: Nature<br/><br/>Zeolitic imidazolate frameworks (ZIFs) are porous crystalline materials with tetrahedral networks that resemble those of zeolites: transition metals (Zn, Co) replace tetrahedrally coordinated atoms (for example, Si), and imidazolate links replace oxygen bridges. A striking feature of these materials is that the structure adopted by a given ZIF is determined by link-link interactions, rather than by the structure directing agents used in zeolite synthesis. As a result, systematic variations of linker substituents have yielded many different ZIFs that exhibit known or predicted zeolite topologies. The materials are chemically and thermally stable, yet have the long-sought-after design flexibility offered by functionalized organic links and a high density of transition metal ions. Here we report the synthesis and characterization of two porous ZIFs-ZIF-95 and ZIF-100-with structures of a scale and complexity previously unknown in zeolites. The materials have complex cages that contain up to 264 vertices, and are constructed from as many as 7,524 atoms. As expected from the adsorption selectivity recently documented for other members of this materials family, both ZIFs selectively capture carbon dioxide from several different gas mixtures at room temperature, with ZIF-100 capable of storing 28 litres per litre of material at standard temperature and pressure. These characteristics, combined with their high thermal and chemical stability and ease of fabrication, make ZIFs promising candidate materials for strategies aimed at ameliorating increasing atmospheric carbon dioxide levels.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464739&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464738 Publication Date: 2008 May 8 PMID: 18464738<br/>Authors: Bertaina, S. - Gambarelli, S. - Mitra, T. - Tsukerblat, B. - Muller, A. - Barbara, B.<br/>Journal: Nature<br/><br/>The term 'molecular magnet' generally refers to a molecular entity containing several magnetic ions whose coupled spins generate a collective spin, S (ref. 1). Such complex multi-spin systems provide attractive targets for the study of quantum effects at the mesoscopic scale. In these molecules, the large energy barriers between collective spin states can be crossed by thermal activation or quantum tunnelling, depending on the temperature or an applied magnetic field. There is the hope that these mesoscopic spin states can be harnessed for the realization of quantum bits--'qubits', the basic building blocks of a quantum computer--based on molecular magnets. But strong decoherence must be overcome if the envisaged applications are to become practical. Here we report the observation and analysis of Rabi oscillations (quantum oscillations resulting from the coherent absorption and emission of photons driven by an electromagnetic wave) of a molecular magnet in a hybrid system, in which discrete and well-separated magnetic clusters are embedded in a self-organized non-magnetic environment. Each cluster contains 15 antiferromagnetically coupled S = 1/2 spins, leading to an S = 1/2 collective ground state. When this system is placed into a resonant cavity, the microwave field induces oscillatory transitions between the ground and excited collective spin states, indicative of long-lived quantum coherence. The present observation of quantum oscillations suggests that low-dimension self-organized qubit networks having coherence times of the order of 100 micros (at liquid helium temperatures) are a realistic prospect.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464738&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464737 Publication Date: 2008 May 8 PMID: 18464737<br/>Authors: Fouchet, T. - Guerlet, S. - Strobel, D. F. - Simon-Miller, A. A. - Bezard, B. - Flasar, F. M.<br/>Journal: Nature<br/><br/>The middle atmospheres of planets are driven by a combination of radiative heating and cooling, mean meridional motions, and vertically propagating waves (which originate in the deep troposphere). It is very difficult to model these effects and, therefore, observations are essential to advancing our understanding of atmospheres. The equatorial stratospheres of Earth and Jupiter oscillate quasi-periodically on timescales of about two and four years, respectively, driven by wave-induced momentum transport. On Venus and Titan, waves originating from surface-atmosphere interaction and inertial instability are thought to drive the atmosphere to rotate more rapidly than the surface (superrotation). However, the relevant wave modes have not yet been precisely identified. Here we report infrared observations showing that Saturn has an equatorial oscillation like those found on Earth and Jupiter, as well as a mid-latitude subsidence that may be associated with the equatorial motion. The latitudinal extent of Saturn's oscillation shows that it obeys the same basic physics as do those on Earth and Jupiter. Future highly resolved observations of the temperature profile together with modelling of these three different atmospheres will allow us determine the wave mode, the wavelength and the wave amplitude that lead to middle atmosphere oscillation.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464737&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464736 Publication Date: 2008 May 8 PMID: 18464736<br/>Authors: Orton, G. S. - Yanamandra-Fisher, P. A. - Fisher, B. M. - Friedson, A. J. - Parrish, P. D. - Nelson, J. F. - Bauermeister, A. S. - Fletcher, L. - Gezari, D. Y. - Varosi, F. - Tokunaga, A. T. - Caldwell, J. - Baines, K. H. - Hora, J. L. - Ressler, M. E. - Fujiyoshi, T. - Fuse, T. - Hagopian, H. - Martin, T. Z. - Bergstralh, J. T. - Howett, C. - Hoffmann, W. F. - Deutsch, L. K. - Van Cleve, J. E. - Noe, E. - Adams, J. D. - Kassis, M. - Tollestrup, E.<br/>Journal: Nature<br/><br/>Observations of oscillations of temperature and wind in planetary atmospheres provide a means of generalizing models for atmospheric dynamics in a diverse set of planets in the Solar System and elsewhere. An equatorial oscillation similar to one in the Earth's atmosphere has been discovered in Jupiter. Here we report the existence of similar oscillations in Saturn's atmosphere, from an analysis of over two decades of spatially resolved observations of its 7.8-microm methane and 12.2-microm ethane stratospheric emissions, where we compare zonal-mean stratospheric brightness temperatures at planetographic latitudes of 3.6 degrees and 15.5 degrees in both the northern and the southern hemispheres. These results support the interpretation of vertical and meridional variability of temperatures in Saturn's stratosphere as a manifestation of a wave phenomenon similar to that on the Earth and in Jupiter. The period of this oscillation is 14.8 +/- 1.2 terrestrial years, roughly half of Saturn's year, suggesting the influence of seasonal forcing, as is the case with the Earth's semi-annual oscillation.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464736&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464735 Publication Date: 2008 May 8 PMID: 18464735<br/>Authors: Abbondanzieri, E. A. - Bokinsky, G. - Rausch, J. W. - Zhang, J. X. - Le Grice, S. F. - Zhuang, X.<br/>Journal: Nature<br/><br/>The reverse transcriptase of human immunodeficiency virus (HIV) catalyses a series of reactions to convert the single-stranded RNA genome of HIV into double-stranded DNA for host-cell integration. This task requires the reverse transcriptase to discriminate a variety of nucleic-acid substrates such that active sites of the enzyme are correctly positioned to support one of three catalytic functions: RNA-directed DNA synthesis, DNA-directed DNA synthesis and DNA-directed RNA hydrolysis. However, the mechanism by which substrates regulate reverse transcriptase activities remains unclear. Here we report distinct orientational dynamics of reverse transcriptase observed on different substrates with a single-molecule assay. The enzyme adopted opposite binding orientations on duplexes containing DNA or RNA primers, directing its DNA synthesis or RNA hydrolysis activity, respectively. On duplexes containing the unique polypurine RNA primers for plus-strand DNA synthesis, the enzyme can rapidly switch between the two orientations. The switching kinetics were regulated by cognate nucleotides and non-nucleoside reverse transcriptase inhibitors, a major class of anti-HIV drugs. These results indicate that the activities of reverse transcriptase are determined by its binding orientation on substrates.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464735&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464734 Publication Date: 2008 May 8 PMID: 18464734<br/>Authors: Warren, W. C. - Hillier, L. W. - Marshall Graves, J. A. - Birney, E. - Ponting, C. P. - Grutzner, F. - Belov, K. - Miller, W. - Clarke, L. - Chinwalla, A. T. - Yang, S. P. - Heger, A. - Locke, D. P. - Miethke, P. - Waters, P. D. - Veyrunes, F. - Fulton, L. - Fulton, B. - Graves, T. - Wallis, J. - Puente, X. S. - Lopez-Otin, C. - Ordonez, G. R. - Eichler, E. E. - Chen, L. - Cheng, Z. - Deakin, J. E. - Alsop, A. - Thompson, K. - Kirby, P. - Papenfuss, A. T. - Wakefield, M. J. - Olender, T. - Lancet, D. - Huttley, G. A. - Smit, A. F. - Pask, A. - Temple-Smith, P. - Batzer, M. A. - Walker, J. A. - Konkel, M. K. - Harris, R. S. - Whittington, C. M. - Wong, E. S. - Gemmell, N. J. - Buschiazzo, E. - Vargas Jentzsch, I. M. - Merkel, A. - Schmitz, J. - Zemann, A. - Churakov, G. - Kriegs, J. O. - Brosius, J. - Murchison, E. P. - Sachidanandam, R. - Smith, C. - Hannon, G. J. - Tsend-Ayush, E. - McMillan, D. - Attenborough, R. - Rens, W. - Ferguson-Smith, M. - Lefevre, C. M. - Sharp, J. A. - Nicholas, K. R. - Ray, D. A. - Kube, M. - Reinhardt, R. - Pringle, T. H. - Taylor, J. - Jones, R. C. - Nixon, B. - Dacheux, J. L. - Niwa, H. - Sekita, Y. - Huang, X. - Stark, A. - Kheradpour, P. - Kellis, M. - Flicek, P. - Chen, Y. - Webber, C. - Hardison, R. - Nelson, J. - Hallsworth-Pepin, K. - Delehaunty, K. - Markovic, C. - Minx, P. - Feng, Y. - Kremitzki, C. - Mitreva, M. - Glasscock, J. - Wylie, T. - Wohldmann, P. - Thiru, P. - Nhan, M. N. - Pohl, C. S. - Smith, S. M. - Hou, S. - Renfree, M. B. - Mardis, E. R. - Wilson, R. K.<br/>Journal: Nature<br/><br/>We present a draft genome sequence of the platypus, Ornithorhynchus anatinus. This monotreme exhibits a fascinating combination of reptilian and mammalian characters. For example, platypuses have a coat of fur adapted to an aquatic lifestyle; platypus females lactate, yet lay eggs; and males are equipped with venom similar to that of reptiles. Analysis of the first monotreme genome aligned these features with genetic innovations. We find that reptile and platypus venom proteins have been co-opted independently from the same gene families; milk protein genes are conserved despite platypuses laying eggs; and immune gene family expansions are directly related to platypus biology. Expansions of protein, non-protein-coding RNA and microRNA families, as well as repeat elements, are identified. Sequencing of this genome now provides a valuable resource for deep mammalian comparative analyses, as well as for monotreme biology and conservation.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464734&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464733 Publication Date: 2008 May 8 PMID: 18464733<br/>Authors: de Greef, T. F. - Meijer, E. W.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464733&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464732 Publication Date: 2008 May 8 PMID: 18464732<br/>Authors: Shadan, S.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464732&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464731 Publication Date: 2008 May 8 PMID: 18464731<br/>Authors: Arnold, E. - Sarafianos, S. G.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464731&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464730 Publication Date: 2008 May 8 PMID: 18464730<br/>Authors: Stamp, P. C.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464730&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464729 Publication Date: 2008 May 8 PMID: 18464729<br/>Authors: Westervelt, R. M.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464729&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464728 Publication Date: 2008 May 8 PMID: 18464728<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464728&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464727 Publication Date: 2008 May 8 PMID: 18464727<br/>Authors: Ghirlanda, G.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464727&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464726 Publication Date: 2008 May 8 PMID: 18464726<br/>Authors: Dowling, T. E.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464726&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464725 Publication Date: 2008 May 8 PMID: 18464725<br/>Authors: Ball, P.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464725&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464724 Publication Date: 2008 May 8 PMID: 18464724<br/>Authors: Chiari, G.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464724&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464723 Publication Date: 2008 May 8 PMID: 18464723<br/>Authors: Turney, C.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464723&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464722 Publication Date: 2008 May 8 PMID: 18464722<br/>Authors: Marris, E.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464722&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464721 Publication Date: 2008 May 8 PMID: 18464721<br/>Authors: Hood, B. M.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464721&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464720 Publication Date: 2008 May 8 PMID: 18464720<br/>Authors: Gingerich, O.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464720&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464719 Publication Date: 2008 May 8 PMID: 18464719<br/>Authors: Richels, R. G. - Tol, R. S. - Yohe, G. W.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464719&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464718 Publication Date: 2008 May 8 PMID: 18464718<br/>Authors: Edenhofer, O. - Hare, B. - Knopf, B. - Luderer, G.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464718&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464717 Publication Date: 2008 May 8 PMID: 18464717<br/>Authors: Romm, J.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464717&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464716 Publication Date: 2008 May 8 PMID: 18464716<br/>Authors: Smil, V.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464716&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464715 Publication Date: 2008 May 8 PMID: 18464715<br/>Authors: Field, C. B.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464715&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464714 Publication Date: 2008 May 8 PMID: 18464714<br/>Authors: Pearson, H.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464714&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464713 Publication Date: 2008 May 8 PMID: 18464713<br/>Authors: Courtland, R.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464713&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464712 Publication Date: 2008 May 8 PMID: 18464712<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464712&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464711 Publication Date: 2008 May 8 PMID: 18464711<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464711&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464710 Publication Date: 2008 May 8 PMID: 18464710<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464710&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464709 Publication Date: 2008 May 8 PMID: 18464709<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464709&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464708 Publication Date: 2008 May 8 PMID: 18464708<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464708&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464707 Publication Date: 2008 May 8 PMID: 18464707<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464707&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464706 Publication Date: 2008 May 8 PMID: 18464706<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464706&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464705 Publication Date: 2008 May 8 PMID: 18464705<br/>Authors: Butler, D.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464705&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464704 Publication Date: 2008 May 8 PMID: 18464704<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464704&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464703 Publication Date: 2008 May 8 PMID: 18464703<br/>Authors: Hand, E.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464703&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464702 Publication Date: 2008 May 8 PMID: 18464702<br/>Authors: Wadman, M.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464702&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464701 Publication Date: 2008 May 8 PMID: 18464701<br/>Authors: Brumfiel, G.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464701&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464700 Publication Date: 2008 May 8 PMID: 18464700<br/>Authors: Brown, S.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464700&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464699 Publication Date: 2008 May 8 PMID: 18464699<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464699&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464698 Publication Date: 2008 May 8 PMID: 18464698<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464698&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464697 Publication Date: 2008 May 8 PMID: 18464697<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464697&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464696 Publication Date: 2008 May 8 PMID: 18464696<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464696&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464695 Publication Date: 2008 May 8 PMID: 18464695<br/>Authors: Balloux, F.<br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464695&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464694 Publication Date: 2008 May 8 PMID: 18464694<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464694&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464693 Publication Date: 2008 May 8 PMID: 18464693<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464693&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464692 Publication Date: 2008 May 8 PMID: 18464692<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464692&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464691 Publication Date: 2008 May 8 PMID: 18464691<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464691&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464690 Publication Date: 2008 May 8 PMID: 18464690<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464690&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464689 Publication Date: 2008 May 8 PMID: 18464689<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464689&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464688 Publication Date: 2008 May 8 PMID: 18464688<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464688&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464687 Publication Date: 2008 May 8 PMID: 18464687<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464687&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=18464686 Publication Date: 2008 May 8 PMID: 18464686<br/>Authors: <br/>Journal: Nature<br/><br/><br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D18464686&title=Entrez+P