http://barf.jcowboy.org Journal of Biology recent publications en-us http://barf.jcowboy.org/pubmed.gif http://barf.jcowboy.org http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20156328 Publication Date: 2010 Feb 11 PMID: 20156328<br/>Authors: Harvey, K. F.<br/>Journal: J Biol<br/><br/>ABSTRACT: By combining Drosophila genetics and proteomics Gluderer et al. report in this issue of Journal of Biology the isolation of a novel growth-regulatory complex consisting of Bunched and Madm. Future study of this complex will address the precise mechanism of growth control, regulation of complex activity, the interface with other growth pathways and a potential role in human cancer.See research article at http://jbiol.com/content/9/1/9.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D20156328&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20156326 Publication Date: 2010 Feb 10 PMID: 20156326<br/>Authors: Gallo, M. - Riddle, D. L.<br/>Journal: J Biol<br/><br/>ABSTRACT: The nematode Caenorhabditis elegans is a favorite model for the study of aging. A wealth of genetic and genomic studies show that metabolic regulation is a hallmark of life-span modulation. A recent study in BMC Biology identifying metabolic signatures for longevity suggests that amino-acid pools may be important in longevity.See research article http://www.biomedcentral.com/1741-7007/8/14.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D20156326&title=Entrez+Pubmed">CiteULike</a> http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&dopt=Abstract&list_uids=20149264 Publication Date: 2010 Feb 11 PMID: 20149264<br/>Authors: Gluderer, S. - Brunner, E. - Germann, M. - Jovaisaite, V. - Li, C. - Rentsch, C. A. - Hafen, E. - Stocker, H.<br/>Journal: J Biol<br/><br/>ABSTRACT: BACKGROUND: The TSC-22 domain family (TSC22DF) consists of putative transcription factors harboring a DNA-binding TSC-box and an adjacent leucine zipper at their carboxyl termini. Both short and long TSC22DF isoforms are conserved from flies to humans. Whereas the short isoforms include the tumor suppressor TSC-22 (Transforming growth factor-beta1 stimulated clone-22), the long isoforms are largely uncharacterized. In Drosophila, the long isoform Bunched A (BunA) acts as a growth promoter, but how BunA controls growth has remained obscure. RESULTS: In order to test for functional conservation among TSC22DF members, we expressed the human TSC22DF proteins in the fly and found that all long isoforms can replace BunA function. Furthermore, we combined a proteomics-based approach with a genetic screen to identify proteins that interact with BunA. Madm (Mlf1 adapter molecule) physically associates with BunA via a conserved motif that is only contained in long TSC22DF proteins. Moreover, Drosophila Madm acts as a growth-promoting gene that displays growth phenotypes strikingly similar to bunA phenotypes. When overexpressed, Madm and BunA synergize to increase organ growth. CONCLUSIONS: The growth-promoting potential of long TSC22DF proteins is evolutionarily conserved. Furthermore, we provide biochemical and genetic evidence for a growth-regulating complex involving the long TSC22DF protein BunA and the adapter molecule Madm.See minireview at http://jbiol.com/content/9/1/8.<br/><br/>post to: <a href = "http://www.citeulike.org/posturl?url=http%3A%2F%2Fwww.ncbi.nlm.nih.gov%2Fentrez%2Fquery.fcgi%3Fcmd%3DRetrieve%26db%3DPubMed%26dopt%3DAbstract%26list_uids%3D20149264&title=Entrez+Pubmed">CiteULike</a>